Breast Carcinoma Grade Calculator

icon Breast Carcinoma Grade Calculator

1. Microscope Calibration

? The value printed on your eyepiece (e.g. 20, 22, 25). Used to automatically establish the exact field size limits.
Printed on eyepiece (e.g., 22)
? The magnification setting of the objective lens used during evaluation (typically 40).
Typically 40x for mitoses
? Approximate count of how many typical tumor cells line up end-to-end across the calculated field diameter.

2. Histologic Component Scoring

? Score based on percentage of tumor forming distinct tubular lumina structures.
? Evaluation of variation in nuclear size and shape relative to normal epithelial cells.
? Enter the raw number of mitotic figures counted across 10 consecutive high-power fields. The score cutoffs shift automatically with your field diameter above.
Standard raw count across 10 consecutive fields
Field Diameter: 0.55 mm (550 µm)
Estimated Cell Size: 110.0 µm
Mitotic count cutoffs for this field (1 / 2 / 3): —
Tubule score: 2
Pleomorphism score: 2
Mitotic score: 1
Total Nottingham Score: 5 / 9
Grade 1 — Well differentiated
Based on the Nottingham combined histologic grade (Elston-Ellis modification of the Scarff-Bloom-Richardson system). Mitotic count cutoffs are field-diameter dependent per CAP/College of American Pathologists guidance. This tool is a calculation aid only and does not replace professional pathological judgment.